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| Cell Lineage Modulation |
Mankind has long wondered whether it might be possible to regenerate body tissues and structures that have been lost. Recent research has shown that even the adult body contains a diverse range of tissue-specific somatic stem cells that serve to maintain the function and integrity of tissues, opening a promising avenue toward possible applications in regenerative medicine. But the limits on the number of somatic stem cells present in any individual, coupled with the limited availability of donors, have heightened interest in the development of new, alternative means of generating new stem cells.
Research in our lab seeks to develop a better understanding of the molecular mechanisms involved in the reacquisition of gstemnessh (stem cell characteristics) using the dedifferentiation of oligodendrocyte progenitor cells (OPCs), which are abundantly present in the central nervous system, into neural stem-like cells, knowledge which it is hoped may lead to new techniques for the generation of neural stem cells. We are also interested in studying the characteristics of stem-like cells found in malignant tumors, with an eye toward the potential development of novel anti-cancer therapies. |
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Kujuro Y, et al. Esophageal cancer-related gene 4 is a secreted inducer of cell senescence expressed by aged CNS precursor cells. Proceedings of the National Academy of Sciences. 107.8259-64 (2010)
Hide T, et al. Sox11 prevents tumorigenesis of glioma-initiating cells by inducing neuronal differentiation. Cancer Res. 69. 7953-7959 (2009)
Murase M, et al. Side population cells have the characteristics of cancer stem-like cells/cancer-initiating cells in bone sarcomas. Br J Cancer 101. 1425-1432 (2009)
Nishide K, et al. Gliomagenesis from transformed neural stem cells depleted of prominin1-expressing cells. PLoS ONE 4. E6869 (2009)
Takanaga H, et al. Gli2 Is A Novel Regulator of Sox2 Expression In Telencephalic Neuroepithelial Cells. Stem Cells 27. 165-174 (2009)
Kondo T Making of glioma-initiating cells. Inflamation and Regeneration 28.537-542 (2008)
Kondo T. Stem cell-like glioma cells. Current cancer therapy Review 4. 201-205 (2008)
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