Organ Regeneration | Tooth Regeneration

Future problem

Future problem

We have demonstrated a novel, three-dimensional bioengineering method for generating organ germ from teeth and hair follicles (Nature Methods, 2007). This has significantly advanced the promise of future organ replacement regenerative therapies. Recently, we reported a successful, fully functioning bioengineered tooth replacement through the transplantation of bioengineered tooth germ into an adult oral environment (PNAS, 2009). In addition, we demonstrated further developments in which a bioengineered tooth unit was successfully transplanted into the alveolar bone through bone integration by recipient bone remodeling in a murine transplantation model system (PLoS ONE, 2011).

Further studies identifying available adult tissue stem cells and inductive signals for the reconstitution of a bioengineered tooth germ will be required to realize clinical whole tooth regenerative therapy.
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