Speakers

HR Rodewald is head of the Division for Cellular Immunology at the German Cancer Research Center in Heidelberg. HR Rodewald’s laboratory has a long-standing interest in the development of lineages and organs in the immune system. The laboratory has developed fate mapping systems to trace the output of hematopoietic stem cells (HSC) in vivo under physiological conditions, to unravel HSC fates realized in vivo and to infer hematopoietic pathways. To this end, the Rodewald laboratory generated inducible Cre recombinase knockin mice to activate fluorescent markers in HSC in situ (Busch et al. Nature 2015). To resolve realized fates emerging from HSC (or other stem cells) in vivo, the laboratory has generated an endogenous barcoding system which is based on Cre-driven DNA recombination in an artificial locus (termed Polylox) in mice (Pei, Feyerabend et al. Nature 2017). Members of the laboratory work on a model of T cell acute lymphoblastic leukemia (T-ALL) in which transformation is controlled by cell competition (Martins et al. Nature 2014). Further interests in the laboratory are the physiological functions of mast cells, tissue resident macrophages (Gomez Perdiguero, Klapproth et al. Nature 2015) versus recruited local macrophages, and aspects of thymus organogenesis.