Environment dictates behaviour

The cellular microenvironment is an integral part of our body, which sends essential signals to resident cells to control their fate and behaviours. However, little is known about the molecular identity, dynamics and action of the extracellular space. The broad goal of our lab is to discover the principles of cell-microenvironment interactions that instruct cellular behaviour and communication, and the formation of organs. By focusing on skin biology, we are currently studying the following two mutually-related themes 1) cell–extracellular matrix (ECM) interactions and 2) crosstalk between skin stem cells and their microenvironment or niche.
Ref: Baumann K, Nat Rev Mol Cell Biol 2010

> News + Events

[Published] (9 June 2021)
Morita R, Sanzen N, Sasaki H, Hayashi T, Umeda M, Yoshimura M, Yamamoto T, Shibata T, Abe T, Kiyonari H, Furuta Y, Nikaido I, Fujiwara H (2021)
Tracing the origin of hair follicle stem cells.
Nature. https://doi.org/10.1038/s41586-021-03638-5. Online ahead of print.
[
Paper]
Featured in
- Nature, NEWS AND VIEWS: A 4D road map for the formation of hair follicles. Saxena N & Rendl M [
Link]
- RIKEN and JST Press Release (Japanese):
毛包幹細胞の起源を解明 [Link], [Link]
Media coverage
- NHK (Japanese) [
Link], 朝日新聞デジタル (Japanese) [Link], Jiji.com (Japanese) [Link], Science Portal (Japanese) [Link], マイナビニュース (Japanese) [Link], etc.

[Published]
(10 May 2021)
Tsutsui K, Machida H, Nakagawa A, Ahn K, Morita R, Sekiguchi K, Miner JH, Fujiwara H (2021)
Mapping the molecular and structural specialization of the skin basement membrane for inter-tissue interactions.
Nature Communications, 12, 2577. https://doi.org/10.1038/s41467-021-22881-y
[
Paper]
Featured in
- RIKEN Press Release (Japanese):
異種組織を一体化する細胞外環境の特性を解明 [Link]
Media coverage
- 日刊工業新聞 (Japanese): 異なる細胞同士接続 理研など、たんぱく質の特性解明 [Link]

[Award] (1 June 2020)
Ritsuko Morita was awarded 13th Shiseido Female Researcher Science Grant.[Link1][Link2]

[Preprint] (28 April 2020)
Tsutsui K, Machida H, Morita R, Nakagawa A, Sekiguchi K, Miner JH, Fujiwara H (2020)
Mapping the molecular and structural specialization of the skin basement membrane for inter-tissue interactions
bioRxiv. doi: https://doi.org/10.1101/2020.04.27.061952 [
Paper]

[Seminar]
(12 March 2020)
(Cancelled) Prof. Riichiro Abe (Department of Dermatology, Niigata University)
Keratinocyte death mechanism in adverse drug reaction.
10:00–11:00, 12 March 2020
DB Bldg. Seminar Room A7F (open seminar)

[Published]
(25 February 2020)
藤原裕展. (2020)
表皮幹細胞がニッチとして機能する. 再生医療, 19(1):13–27
[
Paper]

[Seminar] (13 February 2020)
Dr. Oliver Dreesen (A*STAR/Skin Research Institute of Singapore)
The role of heterochromatin in the accelerated aging syndrome Hutchinson-Gilford progeria
[link].
16:00–17:00, 13 February 2020
DB Bldg. Seminar Room A7F (open seminar)


[
Postdoc position available] (10 December 2019)
We are now recruiting one or two postdoctoral fellows based on a 5-year JST-CREST project "dynamics of epithelial-mesenchymal interactions that underlies the emergence of integumentary diversity"[link]. For more details, please contact Hironobu Fujiwara.

ポストドクトラフフェローを募集しています[link]JST-CRESTプロジェクト「体表多様性を創発する上皮-間充織相互作用の動的制御機構の解明 [link]」に関する研究を推進していただきます。体表(皮膚)が多様な形態と機能を自由に生み出すメカニズムを、細胞間相互作用の時空間発展の1細胞解析を通して明らかにします。CRESTプロジェクトで最長5年間サポートできるポジションです。研究内容などのより詳細な情報は、藤原裕展までお問い合わせください。

[Selected talk]
(13–16 November 2019)
Morita R.
The origin and induction processes of hair follicle stem cells
Cold Spring Harbor Laboratory Meeting: Single Cell Analysis, NY, USA [link]

[Invited talk] (8–10 November 2019)
Fujiwara H.
A new model for coordinated hair follicle morphogenesis and stem cell induction
44th Japanese Society for Investigative Dermatology, Aomori, Japan [link]

[Awards] (7–8 October 2019)
Hiroki Machida was awarded a poster prize in 2019 RIKEN Summer School.

[Funded]
(01 October 2019)
We are now JST-CREST funded to investigate the dynamics of epithelial-mesenchymal interactions that underlies the emergence of integumentary diversity (2019–2025).
私達の研究提案がJST CREST研究(多細胞領域)に採択されました。研究課題「体表多様性を創発する上皮-間充織相互作用の動的制御機構の解明」を、二階堂愛グループ(理研BDR)、長山雅晴グループ(北海道大)とともに推進します(2019–2025)。
turquoise01

[Published]
(01 October 2019)
筒井仰, 藤原裕展. (2019)
皮膚が触覚センサとして機能するしくみ. 自動車技術 超の世界, 100–101, 73 (10), 2019

[Published]
(24 September 2019)
筒井仰, 待田大輝, 藤原裕展. (2019)
細胞外マトリックスの多様性が支える毛包の異種組織間相互作用. 毛髪科学の新展開, 39–47.

[Preprint] (12 September 2019)
Ahn K. and Fujiwara H.
Subpopulation identification for single-cell RNA-sequencing data using functional data analysis [
link]
bioRxiv
doi: https://doi.org/10.1101/760413

[Selected talk] (7–12 July 2019)
Fujiwara H.
A new model for orchestrated hair follicle morphogenesis and stem cell induction
Gordon Research Conference on Epithelial Differentiation and Keratinization, Maine, USA [link]

[Selected talk]
(6–7 July 2019)
Morita R.
The origin and induction processes of hair follicle stem cells
Gordon Research Seminar on Epithelial Differentiation and Keratinization, Maine, USA [link]

[Awards]
(10–12 April 2019)
Ritsuko Morita was awarded a poster prize in Japan-Singapore International Skin Conference 2019. [link]

[Meeting] (10–12 April 2019)
Japan-Singapore International Skin Conference 2019. [link]
Registration is now open!
Venue: Clinical Sciences Building, 11 Mandalay Road, Singapore 308232
Date: 10–12 April, 2019
Hiro Fujiwara is one of the organizers and speakers of this conference.


[Invited talk] (4–5 February 2019)
Fujiwara H.
1st Crick-Beddington Developmental Biology Symposium, The Francis Crick Institute, London, UK. [link]

[Invited talk] (1 February 2019)
Fujiwara H.
Department of Life Science and System Biology & Molecular Biotechnology Center, University of Turin, Italy.

[Published] (18 November 2018)
Fujiwara H, Tsutsui K, Morita R (2018)
Multi-tasking epidermal stem cells: Beyond epidermal maintenance.
Development, Growth & Differentiation, 60, 531-541. [link:DGD]

[Published] (25 October 2018)
Cheng CC, Tsutsui K, Taguchi T, Sanzen N, Nakagawa A, Kakiguchi K, Yonemura S, Tanegashima C, Keeley SD, Kiyonari H, Furuta Y, Tomono Y, Watt FM, Fujiwara H. (2018)
Hair follicle epidermal stem cells define a niche for tactile sensation.
eLife, 2018;7:e38883. [link:eLife] [プレスリリース] [Riken Research – Research highlight]

[Selected talk]
(14–17 October 2018)
Tsutsui K.
ECM omics identifies signature ECMs for the sites of inter-tissue interactions in the mouse hair follicle
American Society for Matrix Biology, Las Vegas, USA
*Ko Tsutsui was awarded a travel award!


[Published] (15 June 2018)
筒井仰, 藤原裕展. (2018)
感覚器としての毛・毛包. わかりやすい感覚器疾患, 76-77.

[Meeting] (26–28 March 2018)
CDB Symposium 2018 "Dynamic Homeostasis: From Development to Aging" [link]
Venue: RIKEN Center for Developmental Biology, Kobe, Japan
Date: 26–28 March 2018
Hiro Fujiwara is one of the organizers and speakers of this conference.


[Published] (25 February 2018)
藤原裕展. (2018)
皮膚再生における幹細胞と微小環境との双方向性シグナリング. コスメティックステージ, 12(3)1-7.