Environment dictates behaviour

The cellular microenvironment is an integral part of our body, which sends essential signals to resident cells to control their fate and behaviours. However, little is known about the molecular identity, dynamics and action of the extracellular space. The broad goal of our lab is to discover the principles of cell-microenvironment interactions that instruct cellular behaviour and communication, and the formation of organs. By focusing on skin biology, we are currently studying the following two mutually-related themes 1) cell–extracellular matrix (ECM) interactions and 2) crosstalk between skin stem cells and their microenvironment or niche.
Ref: Baumann K, Nat Rev Mol Cell Biol 2010

> News + Events


[Awards] (10–12 April 2019)
Ritsuko Morita was awarded a poster prize in Japan-Singapore International Skin Conference 2019. [link]

[Meeting] (10–12 April 2019)
Japan-Singapore International Skin Conference 2019. [link]
Registration is now open!
Venue: Clinical Sciences Building, 11 Mandalay Road, Singapore 308232
Date: 10–12 April, 2019
Hiro Fujiwara is one of the organizers and speakers of this conference.


[Invited talk] (4–5 February 2019)
Fujiwara H.
1st Crick-Beddington Developmental Biology Symposium, The Francis Crick Institute, London, UK. [link]

[Published] (18 November 2018)
Fujiwara H, Tsutsui K, Morita R (2018)
Multi-tasking epidermal stem cells: Beyond epidermal maintenance.
Development, Growth & Differentiation, 60, 531-541. [link:DGD]

[Published] (25 October 2018)
Cheng CC, Tsutsui K, Taguchi T, Sanzen N, Nakagawa A, Kakiguchi K, Yonemura S, Tanegashima C, Keeley SD, Kiyonari H, Furuta Y, Tomono Y, Watt FM, Fujiwara H. (2018)
Hair follicle epidermal stem cells define a niche for tactile sensation.
eLife, 2018;7:e38883. [link:eLife] [プレスリリース] [Riken Research – Research highlight]

[Selected talk]
(14–17 October 2018)
Tsutsui K.
ECM omics identifies signature ECMs for the sites of inter-tissue interactions in the mouse hair follicle
American Society for Matrix Biology, Las Vegas, USA
*Ko Tsutsui was awarded a travel award!


[Published] (15 June 2018)
筒井仰, 藤原裕展. (2018)
感覚器としての毛・毛包. わかりやすい感覚器疾患, 76-77.

[Meeting] (26–28 March 2018)
CDB Symposium 2018 "Dynamic Homeostasis: From Development to Aging" [link]
Venue: RIKEN Center for Developmental Biology, Kobe, Japan
Date: 26–28 March 2018
Hiro Fujiwara is one of the organizers and speakers of this conference.


[Published] (25 February 2018)
藤原裕展. (2018)
皮膚再生における幹細胞と微小環境との双方向性シグナリング. コスメティックステージ, 12(3)1-7.