Publications

Morita R, Sanzen N, Sasaki H, Hayashi T, Umeda M, Yoshimura M, Yamamoto T, Shibata T, Abe T, Kiyonari H, Furuta Y, Nikaido I, Fujiwara H (2021)
Tracing the origin of hair follicle stem cells.
Nature. https://doi.org/10.1038/s41586-021-03638-5. Online ahead of print.
[
Paper]
Featured in
- Nature, NEWS AND VIEWS: A 4D road map for the formation of hair follicles. Saxena N & Rendl M [
Link]

Tsutsui K, Machida H, Nakagawa A, Ahn K, Morita R, Sekiguchi K, Miner JH, Fujiwara H (2021)
Mapping the molecular and structural specialization of the skin basement membrane for inter-tissue interactions.
Nature Communications, 12, 2577. https://doi.org/10.1038/s41467-021-22881-y
[
Paper] [RIKEN Press Release (Japanese)] [日刊工業新聞 (Japanese)]

Ahn K and Fujiwara H (2019)
Subpopulation identification for single-cell RNA-sequencing data using functional data analysis
bioRxiv. doi: https://doi.org/10.1101/760413 [Paper]

Fujiwara H, Tsutsui K, Morita R (2018)
Multi-tasking epidermal stem cells: Beyond epidermal maintenance.
Dev Growth Differ. 60, 531–541 [Paper]

Cheng CC§, Tsutsui K§, Taguchi T§, Sanzen N, Nakagawa A, Kakiguchi K, Yonemura S, Tanegashima C, Keeley SD, Kiyonari H, Furuta Y, Tomono Y, Watt FM, Fujiwara H. (§ equally contributed to this work) (2018)
Hair follicle epidermal stem cells define a niche for tactile sensation.
eLife. 7:e38883 [Paper] [プレスリリース] [Riken Research – Research highlight]

Donati G, Proserpio V, Lichtenberger BM, Natsuga K, Sinclair R, Fujiwara H*, Watt FM*. (*joint corresponding author) (2014)
Epidermal Wnt/β-catenin signaling regulates adipocyte differentiation via secretion of adipogenic factors.
Proc Natl Acad Sci U S A. 111 (15): E1501-1509 [Paper] [CDB News] [CDBニュース]

Fujiwara H. (2014)
Cutaneous Extracellular Matrix
Skin Biology; The Biomedical & Life Science Collection,
Henry Stewart Talks Ltd, London. Tobin DJ. edited [Talk]

Fujiwara H, Ferreira M, Donati G, Marciano DK, Linton JM, Sato Y, Hartner A, Sekiguchi K, Reichardt LF, Watt FM. (2011)
The basement membrane of hair follicle stem cells is a muscle cell niche.
Cell. 144(4): 577-589. [Paper]
* Featured in
1) PaperClip in
Cell. (2011) “How Do Goosebumps Form?” [PaperClip]
2) Nature News & Views: Morgan BA (2011) “Developmental Biology: A hair-raising tale”
Nature. 471: 586-587 [Paper]
3) Editors’ Picks in
J Invest Dermatol (2011) 131, 1591. “Beneath the goosebumps” [Paper]
4) Minireview: Jahoda CAB and Christiano AM. (2011) Niche crosstalk: Intercellular signals at the hair follicle.
Cell. 146: 678-681. [Paper]

Watt FM, Fujiwara H. (2011)
Cell-extracellular matrix interactions in normal and diseased skin.
Cold Spring Harb Perspect Biol. Apr 1;3(4) [Paper]

Ferreira M, Fujiwara H, Morita K, Watt FM. (2009)
An activating β1 integrin mutation increases the conversion of benign to malignant skin tumors.
Cancer Res. 69(4):1334-1342. [Paper]
* Featured in
Nature Reviews Cancer 9, 233 (2009): “Metastasis: A malignant mutation” [Paper]

Fujiwara H, Hayashi Y, Sanzen N, Weber C, Emoto T, Futaki S, Niwa H, Murray P, Edgar D, Sekiguchi K. (2007)
Regulation of mesodermal differentiation of mouse embryonic stem cells by basement membranes.
J Biol Chem. 282(40):29701-29711. [Paper]

McDearmon E, Combs A, Sekiguchi K, Fujiwara H, Ervasti J. (2006)
Brain α-dystroglycan displays unique glycoepitopes and preferential binding to laminin-10/11.
FEBS Lett. 580(14):3381-3385.

Hayashi Y, Weber CN, Emoto T, Fujiwara H, Sanzen N, Futaki S, Sekiguchi K (2005)
A novel large-scale production system for modified basement membrane matrices using gene-swapped parietal endoderm cells.
Matrix Biol. 25(2):85-88.

Nagato S, Nakagawa K, Harada H, Kohno S, Fujiwara H, Sekiguchi K, Ohue S, Iwata S, Ohnishi T. (2005)
Downregulation of laminin α4 chain expression inhibits glioma invasion in vitro and in vivo.
Int J Cancer. 117(1):41-50.

Fujiwara H, Gu J, Sekiguchi K. (2004)
Rac regulates integrin-mediated endothelial cell adhesion and migration on laminin-8.
Exp Cell Res. 292(1):67-77. [Paper]

Nishiuchi R, Murayama O, Fujiwara H, Gu J, Kawakami T, Aimoto S, Wada Y, Sekiguchi K. (2003)
Characterization of the ligand-binding specificities of integrin α3β1 and α6β1 using a panel of purified laminin isoforms containing distinct α chains.
J Biochem (Tokyo). 134(4):497-504.

Khazenzon NM, Ljubimov AV, Lakhter AJ, Fujita M, Fujiwara H, Sekiguchi K, Sorokin LM, Petajaniemi N, Virtanen I, Black KL, Ljubimova JY. (2003)
Antisense inhibition of laminin-8 expression reduces invasion of human gliomas in vitro.
Mol Cancer Ther. 2(10):985-994.

Hattori K, Mabuchi R, Fujiwara H, Sanzen N, Sekiguchi K, Kawai K, Akaza H. (2003)
Laminin expression patterns in human ureteral tissue.
J Urol. 170(5):2040-2043.

Hayashi Y, Kim KH, Fujiwara H, Shimono C, Yamashita M, Sanzen N, Futaki S, Sekiguchi K. (2002)
Identification and recombinant production of human laminin α4 subunit splice variants.
Biochem Biophys Res Commun. 299(3):498-504.

Petajaniemi N, Korhonen M, Kortesmaa J, Tryggvason K, Sekiguchi K, Fujiwara H, Sorokin L, Thornell LE, Wondimu Z, Assefa D, Patarroyo M, Virtanen I. (2002)
Localization of laminin α4-chain in developing and adult human tissues.
J Histochem Cytochem. 50(8):1113-1130.

Fujiwara H, Kikkawa Y, Sanzen N, Sekiguchi K. (2001)
Purification and characterization of human laminin-8. Laminin-8 stimulates cell adhesion and migration through α3β1 and α6β1 integrins.
J Biol Chem. 276(20):17550-17558. [Paper]

Kikkawa Y, Sanzen N, Fujiwara H, Sonnenberg A, Sekiguchi K. (2000)
Integrin binding specificity of laminin-10/11: laminin-10/11 are recognized by α3β1, α6β1 and α6β4 integrins.
J Cell Sci. 113 (Pt 5):869-876.


Reviews in Japanese journals, Book chapters

藤原裕展 (Fujiwara H) (2020)
表皮幹細胞がニッチとして機能する (Epidermal stem cells act as a niche)
再生医療 19(1): 13–27 (Regenerative Medicine 19(1): 13–27)

筒井仰、藤原裕展
. (2019)
皮膚が触覚センサとして機能するしくみ
自動車技術 超の世界. 100–101, 73(10), 2019

筒井仰、待田大輝、藤原裕展
. (2019)
細胞外マトリックスの多様性が支える毛包の異種組織間相互作用
毛髪科学の新展開, 39–47

筒井仰、藤原裕展
. (2018)
感覚器としての毛・毛包
わかりやすい感覚器疾患. 76-77

藤原裕展
. (2018)
皮膚再生における幹細胞と微小環境との双方向性シグナリング
コスメティックステージ. 12 (3): 1-7

藤原裕展. (2013)
毛包幹細胞とそのニッチのクロストーク:新展開へ
細胞工学. 32 (10):

藤原裕展 (2013)
皮膚の幹細胞と再生医療 (Skin stem cells and regenerative medicine)
The Frontiers in Life Science:
幹細胞研究と再生医療 編集: 中内啓光. p208-222
(Stem Cell Research and Regenerative Medicine: Edited by Hiromitsu Nakauchi)

藤原裕展, Watt FM. (2011)
毛包幹細胞の基底膜は筋細胞ニッチである.
細胞工学. 30 (6): 644-645

藤原裕展, 関口清俊. (2008)
細胞外マトリックスによるEMTの制御.
細胞工学. 27 (4): 321-325

藤原裕展, 関口清俊. (2008)
初期胚細胞分化における基底膜の役割
(生体の科学; Japanese). 59 (2): 111-117