News + Events

[Published] (9 June 2021)
Morita R, Sanzen N, Sasaki H, Hayashi T, Umeda M, Yoshimura M, Yamamoto T, Shibata T, Abe T, Kiyonari H, Furuta Y, Nikaido I, Fujiwara H (2021)
Tracing the origin of hair follicle stem cells.
Nature. https://doi.org/10.1038/s41586-021-03638-5. Online ahead of print.
[
Paper]
Featured in
- Nature, NEWS AND VIEWS: A 4D road map for the formation of hair follicles. Saxena N & Rendl M [
Link]
- RIKEN and JST Press Release (Japanese):
毛包幹細胞の起源を解明 [Link], [Link]
Media coverage
- NHK (Japanese) [
Link], 朝日新聞デジタル (Japanese) [Link], Jiji.com (Japanese) [Link], Science Portal (Japanese) [Link], マイナビニュース (Japanese) [Link], etc.

[Published]
(10 May 2021)
Tsutsui K, Machida H, Nakagawa A, Ahn K, Morita R, Sekiguchi K, Miner JH, Fujiwara H (2021)
Mapping the molecular and structural specialization of the skin basement membrane for inter-tissue interactions.
Nature Communications, 12, 2577. https://doi.org/10.1038/s41467-021-22881-y
[
Paper]
Featured in
- RIKEN Press Release (Japanese)
異種組織を一体化する細胞外環境の特性を解明
- 日刊工業新聞 (Japanese)
異なる細胞同士接続 理研など、たんぱく質の特性解明

[Award]
(1 June 2020)
Ritsuko Morita was awarded 13th Shiseido Female Researcher Science Grant.[Link1][Link2]

[Preprint]
(28 April 2020)
Tsutsui K, Machida H, Morita R, Nakagawa A, Sekiguchi K, Miner JH, Fujiwara H (2020)
Mapping the molecular and structural specialization of the skin basement membrane for inter-tissue interactions
bioRxiv. doi: https://doi.org/10.1101/2020.04.27.061952 [
Paper]

[Seminar]
(12 March 2020)
Prof. Riichiro Abe (Department of Dermatology, Niigata University)
Keratinocyte death mechanism in adverse drug reaction.
10:00–11:00, 12 March 2020
DB Bldg. Seminar Room A7F (open seminar)

[Published]
(25 February 2020)
藤原裕展. (2020)
表皮幹細胞がニッチとして機能する. 再生医療, 19(1):13–27
[
Paper]

[Seminar] (13 February 2020)
Dr. Oliver Dreesen (A*STAR/Skin Research Institute of Singapore)
The role of heterochromatin in the accelerated aging syndrome Hutchinson-Gilford progeria
[link].
16:00–17:00, 13 February 2020
DB Bldg. Seminar Room A7F (open seminar)

[Postdoc position available] (10 December 2019)
We are now recruiting one or two postdoctoral fellows based on a 5-year JST-CREST project "dynamics of epithelial-mesenchymal interactions that underlies the emergence of integumentary diversity"[link]. For more details, please contact Hironobu Fujiwara.

ポストドクトラフフェローを募集しています[link]JST-CRESTプロジェクト「体表多様性を創発する上皮-間充織相互作用の動的制御機構の解明 [link]」に関する研究を推進していただきます。体表(皮膚)が多様な形態と機能を自由に生み出すメカニズムを、細胞間相互作用の時空間発展の1細胞解析を通して明らかにします。CRESTプロジェクトで最長5年間サポートできるポジションです。研究内容などのより詳細な情報は、藤原裕展までお問い合わせください。

[Selected talk]
(13–16 November 2019)
Morita R.
The origin and induction processes of hair follicle stem cells
Cold Spring Harbor Laboratory Meeting: Single Cell Analysis, NY, USA [link]

[Invited talk] (8–10 November 2019)
Fujiwara H.
A new model for coordinated hair follicle morphogenesis and stem cell induction
44th Japanese Society for Investigative Dermatology, Aomori, Japan [link]

[Awards] (7–8 October 2019)
Hiroki Machida was awarded a poster prize in 2019 RIKEN Summer School.

[Funded]
(01 October 2019)
We are now JST-CREST funded to investigate the dynamics of epithelial-mesenchymal interactions that underlies the emergence of integumentary diversity (2019–2025).
私達の研究提案がJST CREST研究(多細胞領域)に採択されました。研究課題「体表多様性を創発する上皮-間充織相互作用の動的制御機構の解明」を、二階堂愛グループ(理研BDR)、長山雅晴グループ(北海道大)とともに推進します(2019–2025)。
turquoise01

[Published]
(01 October 2019)
筒井仰, 藤原裕展. (2019)
皮膚が触覚センサとして機能するしくみ. 自動車技術 超の世界, 100–101, 73 (10), 2019

[Published]
(24 September 2019)
筒井仰, 待田大輝, 藤原裕展. (2019)
細胞外マトリックスの多様性が支える毛包の異種組織間相互作用. 毛髪科学の新展開, 39–47.

[Preprint]
(12 September 2019)
Ahn K. and Fujiwara H.
Subpopulation identification for single-cell RNA-sequencing data using functional data analysis [
link]
bioRxiv
doi: https://doi.org/10.1101/760413

[Selected talk]
(7–12 July 2019)
Fujiwara H.
A new model for orchestrated hair follicle morphogenesis and stem cell induction
Gordon Research Conference on Epithelial Differentiation and Keratinization, Maine, USA [link]

[Selected talk]
(6–7 July 2019)
Morita R.
The origin and induction processes of hair follicle stem cells
Gordon Research Seminar on Epithelial Differentiation and Keratinization, Maine, USA [link]

[Awards]
(10–12 April 2019)
Ritsuko Morita was awarded a poster prize in Japan-Singapore International Skin Conference 2019. [link]

[Meeting] (10–12 April 2019)
Japan-Singapore International Skin Conference 2019. [link]
Registration is now open!
Venue: Clinical Sciences Building, 11 Mandalay Road, Singapore 308232
Date: 10–12 April, 2019
Hiro Fujiwara is one of the organizers and speakers of this conference.



[Invited talk] (4–5 February 2019)
Fujiwara H.
1st Crick-Beddington Developmental Biology Symposium, The Francis Crick Institute, London, UK. [link]

[Invited talk] (1 February 2019)
Fujiwara H.
Department of Life Science and System Biology & Molecular Biotechnology Center, University of Turin, Italy.

[Published] (18 November 2018)
Fujiwara H, Tsutsui K, Morita R (2018)
Multi-tasking epidermal stem cells: Beyond epidermal maintenance.
Development, Growth & Differentiation, 60, 531-541. [link:DGD]


[Published] (25 October 2018)
Cheng CC, Tsutsui K, Taguchi T, Sanzen N, Nakagawa A, Kakiguchi K, Yonemura S, Tanegashima C, Keeley SD, Kiyonari H, Furuta Y, Tomono Y, Watt FM, Fujiwara H. (2018)
Hair follicle epidermal stem cells define a niche for tactile sensation.
eLife, 2018;7:e38883. [link:eLife] [プレスリリース] [Riken Research – Research highlight]



[Selected talk]
(14–17 October 2018)
Tsutsui K.
ECM omics identifies signature ECMs for the sites of inter-tissue interactions in the mouse hair follicle
American Society for Matrix Biology, Las Vegas, USA
*Ko Tsutsui was awarded a travel award!


[Published] (15 June 2018)
筒井仰, 藤原裕展. (2018)
感覚器としての毛・毛包. わかりやすい感覚器疾患, 76-77.

[Meeting] (26–28 March 2018)
CDB Symposium 2018 "Dynamic Homeostasis: From Development to Aging" [link]
Venue: RIKEN Center for Developmental Biology, Kobe, Japan
Date: 26–28 March 2018
Hiro Fujiwara is one of the organizers and speakers of this symposium.


[Published] (25 February 2018)
藤原裕展. (2018)
皮膚再生における幹細胞と微小環境との双方向性シグナリング. コスメティックステージ, 12(3)1-7.

[Invited talk] (30 November–1 December 2017)
Fujiwara H.
Origin and induction processes of hair follicle stem cells.
Human Cell Atlas Asia Meeting, Okinawa, Japan

[Invited talk] (31 October–3 November 2017)
Fujiwara H.
Plenary Lecture: Reciprocal interactions between epidermal stem cells and their environment.
World Congress for Hair Research 2017, Kyoto, Japan

[Selected talk] (16–21 July 2017)
Tsutsui K.
Mapping the ECM specific to the sites of inter-tissue interactions in the hair follicle
Gordon Research Conference on Collagen, New London, USA

[Selected talk] (7–12 May 2017)
Fujiwara H.
Hair follicle epidermal stem cells define a niche for tactile sensation
Gordon Research Conference on Epithelial Differentiation & Keratinization, Lucca, Italy

[Meeting] (14–15 November 2016)
27th CDB Meeting “Body Surface Tactics: cellular crosstalk for the generation of super-biointerfaces [link]
来る20161114日(月)、15日(火)に理化学研究所 多細胞システム形成研究センター(CDB)におきまして、第27CDBミーティング Body surface tactics: cellular crosstalk for the generation of super-biointerfaces」を開催いたします。
We are pleased to announce that the 27th CDB Meeting "Body surface tactics: Cellular crosstalk for the generation of super-biointerfaces" will be held on November 14 (Monday) and 15 (Tuesday), 2016 at the RIKEN Center for Developmental Biology in Kobe, Japan.
Hiro Fujiwara is one of the organizers and speakers of this meeting.
poster

[Selected talk] (20–24 October 2016)
Fujiwara H.
Hair follicle stem cells define a niche for tactile sensation via secretion of a specialized ECM
Montagna Symposium on the Biology of Skin, Portland, USA

[Published] (3 November, 2015) [link]
産経新聞エッセー「想定外の発見が生まれるとき・・・細胞のささやきに耳を傾ける」藤原裕展

[Invited talk] (21–26 September 2015)
Fujiwara H.
Microenvironmental regulation of hair follicle morphogenesis and regeneration.
Seminar "Cell and tissue communication in organogenesis: cutting edge approaches" Foundation Des Treilles, Tourtour, France

大学生のための生命科学研究インターンシップ
(2015-08-03 - 07) [link]
テーマ:毛形成における細胞分化過程の3次元ライブイメージング

[Invited talk] (28–29 January 2015)
Fujiwara H.
The role of extracellular matrix heterogeneity in regulating hair follicle stem cell-niche interactions.
International Symposium on neurovascular wiring, Kyoto, Japan

CDB Seminar (2014-12-11)
Title: How birds create diverse feather colors - Avian melanocyte stem cells and regulation of feather pigment patterns
Speaker: Dr. Sung-Jan Lin (National Taiwan University)
Host: Hironobu Fujiwara

大学生のための生命科学研究インターンシップ (2014-08-04 - 08) [link]
Theme of the Fujiwara lab: 毛包幹細胞の不均一性とその意義
応募締切: 2014530日(金)

[Published] (2014-3-31)
Donati G, Proserpio V, Lichtenberger BM, Natsuga K, Sinclair R, Fujiwara H*, Watt FM*. (2014) (*joint-corresponding authors)
Epidermal Wnt/beta-catenin signaling regulates adipocyte differentiation via secretion of adipogenic factors.
Proc Natl Acad Sci USA, 2014 (111): E1501-1509. [link:PNAS] [CDB News] [CDBニュース]

[Published] (2014)
"Cutaneous extracellular matrix", in Tobin, D.J. (ed.), Skin Biology:, The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London (online at http://hstalks.com/?t=BL1813698-Fujiwara)

CDB Stem Cell Club was picked up by Cell Stem Cell (2013) [link]
International Stem Cell Networks: The Power of Contacts
Cell Stem Cell (2013) 13, 644-647
CDB Stem Cell Club
[link]

[Published] 幹細胞研究と再生医療  中内啓光 (book chapter) 2013 [link]
25章:皮膚の幹細胞と再生医療
藤原裕展 
13441

[Published] 細胞工学 32 (10), 2013
毛髪再生のメディカルサイエンス:毛は生やせるか?
毛包幹細胞とそのニッチのクロストーク:新展開へ
藤原裕展 
Saibo-kogaku

CDB Lecture Program for Graduate Students (CDB連携大学院集中レクチャープログラム) (2013-08-28 - 29)
Hironobu Fujiwara will be talking
Where: CDB Auditorium C1F

CDB internship for summer students (大学生のための生命科学研究インターンシップ) (2013-08-05 - 09)
Theme: 毛包幹細胞とそのニッチの可視化
Host: Fujiwara lab (藤原研究室)

CDB Seminar (2013-07-08)
Title: "Organs, Not Cells" - A vision for the future
Speaker: Prof. Hiromitsu Nakauchi (University of Tokyo)
Host: Hironobu Fujiwara
When: 2013-7-8, 16:00-
Where: CDB Auditorium C1F

[Invited talk] (8 June 2013)
Fujiwara H.
Exploring the design principles of skin architecture.
Taiwanese Society for Investigative Dermatology, Symposium on Stem Cell, Development and Regeneration, Taipei, Taiwan (8 June 2013)

The CDB Stem Cell Club was launched (2013-03-02)