CONTENTS

MONDAY, MAY 10 (Day 1)

(* Selected talks) 9:00 am Registration 9:50 am Opening Remarks by Toshifumi Inada Session 1 [Alternative Splicing] Chair: Mutsuhito Ohno 10:00 am - 10:30 am S1-1 Alternative Splicing Regulatory Networks in Development and Disease Benjamin J. Blencowe (University of Toronto, Canada) 10:30 am - 10:55 am S1-2 Regulation of Tissue-Specific Alternative Splicing in C. elegans Hidehito Kuroyanagi (Tokyo Medical and Dental University, Japan) 10:55 am - 11:25 am Coffee Break Session 2 [RNA and Chromatin] Chair: Kunihiro Ohta 11:25 am - 11:50 am S2-1 Epigenetic Crosstalk Emily Bernstein (Mount Sinai School of Medicine, USA) 11:50 am - 12:20 pm S2-2 Chromodomain Proteins and RNAi-mediated Heterochromatin Assembly Jun-ichi Nakayama (RIKEN Center for Developmental Biology, Japan) 12:20 pm - 1:30 pm Lunch Poster Introduction 1 Chair: Tohru Yoshihisa 1:30 pm - 2:00 pm microRNA-140 Plays Dual Roles both in Cartilage Development and Homeostasis (P03) Hiroshi Asahara (National Research Institute for Child Health and Development, Japan) Muscle Stem Cell Behaviour is Modified by microRNA-27 Regulation of Pax3 Expression (P06) Colin Crist (Institut Pasteur, France) A-to-I RNA Editing Modulates Targeting of Dicer by Ebv-encoded microRNA Bart6 and Viral Latency (P13) Hisashi Iizasa (Hokkaido University, Japan) RNA Polymerase II Elongation-Dependent Regulation of an Exon Network in RNA Processing Factor Genes (P14) Joanna Y. Ip (University of Toronto, Canada) Remodeling of Transport mRNPs to Localized mRNPs in Neurites (P22) Naoyuki Kataoka (Tokyo Medical and Dental University, Japan) Antisense Correction of SMN2 Splicing in the Central Nervous System of Mouse Models of Spinal Muscular Atrophy (P41) Kentaro Sahashi (Cold Spring Harbor Laboratory, USA) Poster Session 1 2:00 pm - 3:30 pm Presenters of Odd-numbered posters should be by their panels for discussion from 2:00 pm - 2:45 pm Presenters of Even-numbered posters should be by their panels for discussion from 2:45 pm - 3:30 pm Session 3 [RNA Transport] Chair: Tetsuro Hirose 3:30 pm - 4:00 pm S3-1 A Mechanism to Measure RNA Length Prior to RNA Export from the Nucleus Mutsuhito Ohno (Kyoto University, Japan) 4:00 pm - 4:25 pm S3-2 Regulation of Gene Expression at the Nuclear Pore Complex Alwin Köhler (Max F. Perutz Laboratories, Austria) 4:25 pm - 4:55 pm S3-3 The Sm Protein Family in Neuronal mRNA Transport Tilmann Achsel (K.U. Leuven, Belgium) 4:55 pm - 5:15 pm Coffee Break Session 4 [miRNA Machinery and Function] Chair: Vasily Vagin 5:15 pm - 5:35 pm S4-1 MicroRNA-9 is Required for Neurogenesis and Axon Pathfinding in Mouse Telencephlalon through the Regulation of Foxg1, Nr2e1, Gsh2, Meis2, and Islet 1* Mikihito Shibata (RIKEN Center for Developmental Biology, Japan) 5:35 pm - 6:05 pm S4-2 Multilayer Checkpoints for miRNA Authenticity Yukihide Tomari (The University of Tokyo, Japan) 6:05 pm - 6:25 pm S4-3 The Molecular Mechanisms of TNRC6 to Induce Translational Repression and Deadenylation in Zebrafish* Yuichiro Mishima (Kobe University, Japan) 6:25 pm - 9:00 pm Reception at CDB Salon

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TUESDAY, MAY 11 (Day 2)

(*Selected talks) Session 5 [RNA Decay and Quality Control] Chair: Ralf-Peter Jansen 9:00 am - 9:30 am S5-1 Aberrant Translation Links with Protein Degradation and mRNA Cleavage Toshifumi Inada (Nagoya University, Japan) 9:30 am - 9:50 am S5-2 Translational Regulation of HAC1 mRNA, of which Translational Stall is Essential for its Unconventional Cytoplasmic Splicing in Budding Yeast* Tohru Yoshihisa (Nagoya University, Japan) 9:50 am - 10:10 am S5-3 Selective Degradation of Nonfunctional Ribosomal RNAs Mediated by the Ubiquitin-proteasome System* Makoto Kitabatake (Kyoto University, Japan) 10:10 am - 10:45 am Coffee Break Session 6 [Nuclear Non-coding RNA] Chair: Benjamin J. Blencowe 10:45 am - 11:15 am S6-1 dsRNA and Noncoding RNAs in Human Embryonic Stem Cells Gordon G. Carmichael (University of Connecticut Health Center, USA) 11:15 am - 11:45 am S6-2 Roles of Noncoding RNAs in Formation and Function of Nuclear Paraspeckles Tetsuro Hirose (National Institute of Advanced Industrial Science and Technology (AIST), Japan) 11:45 am - 12:05 pm S6-3 A Novel Gene Regulatory Mechanism Controlled by Small Nuclear Noncoding RNA 4.5S RNAH Homologous to a Retrotransposon SINE B1* Kentaro Ishida (RIKEN Advanced Science Institute, Japan) 12:05 pm - 1:15 pm Lunch Poster Introduction 2 Chair: Shinichi Nakagawa 1:15 pm - 1:40 pm MALAT-1 Noncoding RNA Regulates Cellular Mobility by Modulating Gene Expressions (P01) Nobuyoshi Akimitsu (The University of Tokyo, Japan) RNA-binding Protein Khd1p and Ccr4-Not Complex Play an Overlapping Role in a Cell Wall Integrity Pathway in Yeast (P15) Kenji Irie (University of Tsukuba, Japan) Hat1-mediated MVH Acetylation Leads to Inhibition of its Activity in the Chromatoid Body (P36) Ippei Nagamori (University of California, Irvine, USA) Angiogenin-Induced tiRNA Represses Translation under Stress (P58) Satoshi Yamasaki (Nagasaki University School of Medicine, Japan) A Novel Role of the PolyA Binding Protein Partner, Paip2A in Translational Control of Late Spermiogenesis (P60) Akiko Yanagiya (McGill University, Canada) Poster Session 2 1:40 pm - 3:30 pm Presenters of Even numbered posters should be by their panels for discussion from 1:45 pm -2:30 pm Presenters of Odd numbered postersshould be by their panels for discussin from 2:30 pm - 3:15 pm Session 7 [RNA Localization] Chair: Florence Marlow 3:30 pm - 4:00 pm S7-1 RNA Transport in the Cytoplasm: How to Get There from Here Kimberly Mowry (Brown University, USA) 4:00 pm - 4:30 pm S7-2 Coordination of mRNA Localization in Budding Yeast Ralf-Peter Jansen (University of Tuebingen, Germany) 4:30 pm - 4:55 pm S7-3 Scrutinising mRNA Transport Mechanisms In Vivo and In Vitro Simon L. Bullock (MRC Laboratory of Molecular Biology, UK) 4:55 pm - 5:15 pm Coffee Break Session 8 [Small RNA Biogenesis] Chair: Mikiko C. Siomi 5:15 pm - 5:45 pm S8-1 Diverse Small RNA Biogenesis Pathways in Fungi Yi Liu (The University of Texas Southwestern Medical Center, USA) 5:45 pm - 6:10 pm S8-2 Comprehensive Analysis Function of Tudor and PIWI Containing Protein Complexes in piRNA Biogenesis during Mouse Germline Development Vasily Vagin (Cold Spring Harbor Laboratory, USA)

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WEDNESDAY, MAY 12 (Day 3)

(*Selected talks) Session 9 [Germ Granule Function] Chair: Kimberley Mowry 9:00 am - 9:30 am S9-1 Repression of Zygotic Transcription and Maternal RNA Degradation in Drosophila Primordial Germ Cells Akira Nakamura (RIKEN Center for Developmental Biology, Japan) 9:30 am - 9:55 am S9-2 Mechanisms Establishing Oocyte Asymmetries and the Animal-Vegetal Axis Florence Marlow (Albert Einstein College of Medicine, USA) 9:55 am - 10:15 am S9-3 Binding of the STAR Domain Protein GLD-1 to a Degenerate RNA Motif Mediates Large Scale mRNA Regulation* Jane Wright (Friedrich Miescher Institute, Switzerland) 10:15 am - 10:45 am Coffee Break Session 10 [RNA in Chromosome Dynamics] Chair: Jun-ichi Nakayama 10:45 am - 11:15 am S10-1 A Partial Loss of Function Mutation in the Mechanism of X Chromosome Inactivation Takashi Sado (Kyushu University, Japan) 11:15 am - 11:45 am S10-2 Activation of X Inactivation Joost Gribnau (Erasmus MC, The Netherlands) 11:45 am - 12:15 pm S10-3 Chromatin Modification Coupled with Cascade Transcription of Long Non-protein-coding RNA in Glucose Starvation Kunihiro Ohta (The University of Tokyo, Japan) 12:15 pm - 1:30 pm Lunch Session 11 [RNA Granules] Chair: Simon Bullock 1:30 pm - 1:55 pm S11-1 Vgl1, a Multi-KH Domain Protein, is a Novel Component of Fission Yeast Stress Granules that Required for Cell Survival under Thermal Stress Shao-Win Wang (National Health Research Institutes, Taiwan) 1:55 pm - 2:15 pm S11-2 RNA-Binding Proteins as Regulators of MAPK Signaling* Reiko Sugiura (Kinki University, Japan) 2:15 pm - 2:35 pm Coffee Break Session 12 [Small RNAs in the Germline] Chair: Yukihide Tomari 2:35 pm - 2:55 pm S12-1 A Conserved Tudor Domain Protein, Tejas, Functions to Repress Retroelements via piRNA Pathway in the Drosophila Germline* Veena Shivagouda Patil (Temasek Life Sciences Laboratory, Singaore) 2:55 pm - 3:15 pm S12-2 Molecular Function of MVH on piRNA Production in Fetal Male Germ Cells* Satomi Kuramochi-Miyagawa (Osaka University, Japan) 3:15 pm - 3:45 pm S12-3 PiRNA Pathway in Drosophila Germlines Mikiko C. Siomi (Keio University, Japan) 3:45 pm - 4:00 pm Closing Remarks by Yukihide Tomari

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POSTER PROGRAM

P01 MALAT-1 Noncoding RNA Regulates Cellular Mobility by Modulating Gene Expressions Nobuyoshi Akimitsu (The University of Tokyo, Japan) P02 Prolonged Expression of Xist Retards X Chromosome Reactivation in the Mouse Germ Line Yuko Amakawa (National Institute of Genetics, Japan) P03 micro-RNA-140 Plays Dual Roles both in Cartilage Development and Homeostasis Hiroshi Asahara (National Research Institute for Child Health and Development, Japan) P04 Global Analysis of Cold Stress-related mRNA Turnover in Arabidopsis Yukako Chiba (Hokkaido University, Japan) P05 Involvement of the Spliceosomal U4 snRNA in Heterochromatic Gene Silencing at Fission Yeast Centromeres Madoka Chinen (Kumamoto University, Japan) P06 Muscle Stem Cell Behaviour is Modified by microRNA-27 Regulation of Pax3 Expression Colin Crist (Institut Pasteur, France) P07 Functional Decay of Nonfunctional 25S rRNA Requires Proteasome Activity Kotaro Fujii (Kyoto University, Japan) P08 Endogenous Small RNAs in the Drosophila Soma Megha Ghildiyal (University of Massachusetts Medical School, USA) P09 Messenger RNA Stability Control of an Immunomodulatory Chemokine, RANTES: a Model Study in a Multifunctional Regulatory T Cell Line, HOZOT Akira Harashima (Hayashibara Biochemical Laboratories, Inc., Japan) P10 Localization of EGD1 (ß-NAC) mRNAs in a Cytoplasmic Aggresome-like Granule in S. cerevisiae Sachiko Hayashi (Kumamoto University, Japan) P11 Analysis of a PARN Deficient Mutant, ABA Hypersensitive Germination2-1, of Arabidopsis Takashi Hirayama (Okayama University, Japan) P12 Novel Function of U7 snRNA in Transcriptional Repression of Histone Gene upon DNA Replication Arrest Takashi Ideue (National Institute of Advanced Industrial Science and Technology, Japan) P13 A-to-I RNA Editing Modulates Targeting of Dicer by Ebv-encoded microRNA Bart6 and Viral Latency Hisashi Iizasa (Hokkaido University, Japan) P14 RNA Polymerase II Elongation-Dependent Regulation of an Exon Network in RNA Processing Factor Genes Joanna Y. Ip (University of Toronto, Canada) P15 RNA-binding Protein Khd1p and Ccr4-Not Complex Play an Overlapping Role in a Cell Wall Integrity Pathway in Yeast Kenji Irie (University of Tsukuba, Japan) P16 Efficient Silencing of DNA Topoisomerase IIbeta in Human Bone Marrow Mesenchymal Stem Cells (hMSCs) by siRNA Transfection Sevim Isik (Fatih University, Turkey) P17 Chaperone Machinery is Required for RISC-loading Shintaro Iwasaki, Maki Kobayashi (The University of Tokyo, Japan) P18 Identification of a Candidate Factor that promotes Nuclear Export of U snRNAs Hiroto Izumi (Kyoto University, Japan) P19 RNA Binding Motif Protein 24 Regulates Myogenin Expression and Promotes Myogenic Differentiation Donghao Jin (National Cardiovascular Center Research Institute, Japan) P20 Selection and Characteriztion of a New Class of RNA Aptamer Therapeutic Causing Cell Death via Ros Generation in Human Breast Cancer Cell Lines MCF 7 Bala Jyoti (Jawaharlal Nehru University, India)(Jawaharlal Nehru University, India) P21 Genetic Analysis of Short ORF Transcripts in Drosophila Yuji Kageyama (National Institute of Basic Biology, Japan) P22 Remodeling of Transport mRNPs to Localized mRNPs in Neurites Naoyuki Kataoka (Tokyo Medical and Dental University, Japan) P23 Roles of a P Body Component, Edc3, in Oskar mRNP Transport and Translational Control in the Drosophila Oocyte Yasuko Kato (RIKEN Center for Development Biology, Japan) P24 An RNA-binding Protein Musashi1 Contributes to Lin28 Function in Let-7-family miRNA Biogenesis Hironori Kawahara (Keio University, Japan) P25 Natural Antisense Transcript Modulates IFN-a1 mRNA Stability Following Paramyxovirus Infection in Human Namalwa B Lymphocytes Tominori Kimura (Ritsumeikan University, Japan) P26 Selective Degradation of Nonfunctional Ribosomal RNAs Mediated by the Ubiquitin-proteasome System Makoto Kitabatake (Kyoto University, Japan) P27 ES-specific microRNAs are Actively Involved in Induction of Pluripotent Stem Cells from Mouse and Human Fibroblasts Michiyo Koyanagi (Kyoto University, Japan) P28 Molecular Function of MVH on piRNA Production in Fetal Male Germ Cells Satomi Kuramochi-Miyagawa (Osaka University, Japan) P29 Identification of Zebrafish Squint RNA Binding Factor 1, Srbf1, which Binds to the Dorsal Localization Element in Squint mRNA Kumari Pooja (Temasek Life Sciences Laboratory, Singapore) P30 RACK1 Participates in Nascent Polypeptide-dependent Translation Arrest Kazushige Kuroha (Nagoya University, Japan) P31 Genomic Organization, Expression and Evolution of Muscle-specific microRNAs Rie Kusakabe (Kobe University, Japan) P32 The 5’-UTR Sequence Features that Contribute to Translational Control in Response to Abiotic Stress in Arabidopsis thaliana Hideyuki Matsuura (Osaka University, Japan) P33 Purification of an Activity that Measures RNA Length from HeLa Nuclear Extracts Asako McCloskey (Kyoto University, Japan) P34 Is the Intron of tRNA Essential forYeast? Shunsuke Mori (Nagoya University, Japan) P35 Structural Basis for the Sequence-specific RNA-recognition Mechanism of Bruno-like Family Proteins Yutaka Muto (RIKEN Systems and Structural Biology Center, Japan) P36 Hat1-mediated MVH Acetylation Leads to Inhibition of its Activity in the Chromatoid Body Ippei Nagamori (University of California, Irvine, USA) P37 siDirect 2.0: an Updated Website to Select Functional, Target-specific siRNA with Reduced Seed-dependent Off-target Effect for Mammalian Functional Genomics Yuki Naito (The University of Tokyo, Japan) P38 Identification of Nuclear Export Signal and Nuclear Localization Signal in Human GW182 Family Proteins Kenji Nishi (The University of Tokyo, Japan) P39 Functional Involvement of Tudor Domain-containing Proteins in the PiRNA Processing Pathway in Drosophila Germlines Kazumichi M. Nishida (Keio University, Japan) P40 A Conserved Tudor Domain Protein, Tejas, Functions to Repress Retroelements via piRNA Pathway in the Drosophila Germline Veena Shivagouda Patil (Temasek Life Sciences Laboratory, Singapore) P41 Antisense Correction of SMN2 Splicing in the Central Nervous System of Mouse Models of Spinal Muscular Atrophy Kentaro Sahashi (Cold Spring Harbor Laboratory, USA) P42 Identification and Characterization of the Factors Required for the Primary PiRNA Pathway in Somatic Cells in Drosophila Gonads Kuniaki Saito (Keio University, Japan) P43 A Possible Link between piRNA Biogenesis and Microtubule Organization in Drosophila Ovaries Kaoru Sato (Keio University, Japan) P44 MAP Kinase Signaling Dependent Regulation of Cell Fate Mediated by the RNA-binding Protein Nrd1 in Fission Yeast Ryosuke Satoh (Kinki University, Japan) P45 MicroRNA-9 is Required for Neurogenesis and Axon Pathfinding in Mouse Telencephlalon through the Regulation of Foxg1, Nr2e1, Gsh2, Meis2, and Islet 1 Mikihito Shibata (RIKEN Center for Developmental Biology, Japan) P46 Piwi Proteins and piRNA in the Pluripotent Stem Cells of the Planarian, Dugesia japonica Norito Shibata (Kyoto University, Japan) P47 A Protein Product of Ci-PEM, a Major Postplasmic/PEM RNA Gene in Ascidians, Plays Crucial Roles in Transcriptional Repression in Germline Blastomeres Maki Shirae-Kurabayashi (RIKEN Center for Developmental Biology, Japan) P48 RNA-Binding Proteins as Regulators of MAPK Signaling Reiko Sugiura (Kinki University, Japan) P49 Up- and Down-regulation of TOR-Raptor and TOR-Rictor Complexes by Semaphorin in C. elegans Shin Takagi (Nagoya University, Japan) P50 Cis-acting RNA Elements and Trans-acting Factors for Nuclear pre-mRNA Retention Toshihiko Takeiwa (Kyoto University, Japan) P51 Tethering of Pab1 Interferes with Non-translated mRNA Decay from 5’ End Tatsuhisa Tsuboi (Nagoya University, Japan) P52 Colocalization of TDP-43, an RNA/DNA-binding Protein, and Survival of Motor Neuron in Nucleus Hitomi Tsuiji (RIKEN Brain Science Institute, Japan) P53 Substrate Recognition by Drosophila Dicer-1 Akihisa Tsutsumi (The University of Tokyo, Japan) P54 Chemical Synthesis and Properties of Stereoregulated Phosphorothioate RNA Takeshi Wada (The University of Tokyo, Japan) P55 Ubp3, an Ubiquitin Protease, is a Novel Stress Granule-Associated Protein that Interacts with Fission Yeast G3BP-Like-Protein Glp1 Chun-Yu Wang (National Health Research Institutes, Taiwan) P56 Binding of the STAR Domain Protein GLD-1 to a Degenerate RNA Motif Mediates Large Scale mRNA Regulation Jane Wright (Friedrich Miescher Institute, Switzerland) P57 Identification of Neural Specific Glycosylation Regulators Using Functional Genomics Miki Yamamoto-Hino (Mitsubishi Kagaku Institute of Life Sciences, Japan) P58 Angiogenin-Induced tiRNA Represses Translation under Stress Satoshi Yamasaki (Nagasaki University, Japan) P59 Development of a Novel Peptide-Oligonucleotide Conjugate for Regulation of Small RNA Function Asako Yamayoshi (Kyoto Institute of Technology, Japan) P60 A Novel Role of the PolyA Binding Protein Partner, Paip2A in Translational Control of Late Spermiogenesis Akiko Yanagiya (McGill University, Canada) P61 The Mirror-image Relationship between Unwinding and Target Recognition Mayuko Yoda (The University of Tokyo, Japan) P62 Structure-function Analysis of PGL-3 that Plays Crucial Roles in Germ Granule Formation in C. elegans Masafumi Yonetani (Osaka University, Japan) P63 Translational Regulation of HAC1 mRNA, of which Translational Stall is Essential for its Unconventional Cytoplasmic Splicing in Budding Yeast Tohru Yoshihisa (Nagoya University, Japan) L01 Alternative Splicing of Mef2c Promoted by Fox-1 during Neural Differentiation in P19 Cells Nor Hakimah Ab Hakim (Japan Advanced Institute of Science and Technology, Japan) L02 Functional Relationship between MAP Kinase Signaling and Pumilio in Fission Yeast Kanako Hagihara (Kinki University, Japan) L03 Silkworm Gonadal Transcriptome Reveals piRNAs Derived from the Sex Determining Region of W Chromosome and their Possible Targets Shinpei Kawaoka (The University of Tokyo, Japan) L04 Distinct miRNA Expression Profiles of Follicle-associated Epithelium (FAE) and Villous Epithelium (VE) Gaku Nakato (RIKEN Research Center for Allergy and Immunology, Japan) L05 Role of Y14 in C. elegans Germline Sexual Differentiation Masami Shiimori (Kobe University, Japan) L06 Comprehensive Analysis and Pathway Analysis of Alternative Splicing during the Neuronal Differentiation of P19 cells Hitoshi Suzuki (Japan Advanced Institute of Science and Technology, Japan) L07 Multiple Post-Transcriptional Pathways are Involved in Infection Program of the Phytopathogenic Fungus Colletotrichum orbiculare Yoshitaka Takano (Kyoto University, Japan) L08 Membrane-bound Protein Ptr10p is Involved in the Nuclear mRNA Export through the TREX2 Complex in Fission Yeast Tokio Tani (Kumamoto University, Japan)

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