 |
|
| Steven Henikoff is a Member
in the Basic Sciences Division of the Fred Hutchinson
Cancer Research Center and an Investigator of the Howard
Hughes Medical Institute. He earned a B.S. degree in Chemistry
from the University of Chicago and a Ph.D. degree in Biochemistry
and Molecular Biology from Harvard University. His postdoctoral
training was with Charles Laird at the University of Washington.
Dr. Henikoff's research has largely been aimed at understanding
distinctions among different chromatin states, primarily
using Drosophila as an experimental organism. Problems
that are being addressed include mechanisms for centromere
maintenance and evolution and for distinguishing euchromatin
and heterochromatin. Recent work has investigated how
variant histones and nucleosome assembly pathways establish
alternative epigenetic states. His group also has been
active in developing methodology, including computational
tools for protein sequence alignment and predicting deleterious
mutations, and functional genomic methodologies for understanding
chromatin and gene regulation. The TILLING method introduced
by his lab is a general strategy for high-throughput reverse
genetics, and it is being offered as a service to the
research community for Arabidopsis and other organisms.
|
 |
|
