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En Li obtained his Ph.D. degree
from MIT in 1992 and joined faculty of Harvard Medical
School as a Principal Investigator in 1993. He is an Associate
Professor of Medicine at Harvard Medical School and also
an Adjunct Professor of Beijing University where he received
his Bachelor of Science degree in 1984. After working
at Massachusetts General Hospital, where he directed a
highly productive research laboratory and a mouse gene
knockout facility, he now serves as the Global Head of
Animal Models of Diseases at the newly established Novartis
Institutes for Biomedical Research in Cambridge, Massachusetts.
En and his team have made important contributions to the
field of epigenetics by discovering a family of DNA methyltransferases
that establish DNA methylation patterns in the mammalian
genome. Their work has advanced the understanding of how
changes of DNA modification may lead to various diseases.
His other research interests and expertise include stem
cell biology, chromatin remodeling, and TGF-b/BMP signaling
pathways in mammalian embryogenesis, angiogenesis, and
cancer.
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