How can a protein that protects the brain during injury be harmful during brain development?　理化学研究所多細胞システム形成研究センター（CDB）

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Category	CDBセミナー
Date and Time	2009-12-25 16:00 - 17:00
Venue	Auditorium C1F
Speaker	Seong-Seng Tan
Affiliation	Howard Florey Institute
Title	How can a protein that protects the brain during injury be harmful during brain development?
Poster	click here to download(PDF)
Host	Fumio Matsuzaki
Summary	Following brain injury (trauma, stroke), harmful substances can cause cell death. The brain has endogenous protective mechanisms; one of this is removal of toxic substances by protein degradation mediated by ubiquitin. Ndfip1 is an endogenous neuroprotective protein. I will discuss the targets of Ndfip1 ubiquiitination that promotes cell survival and mechanisms behind this. In the embryo, Ndfip1 is important for a different purpose, for regulating cell division of neuroprogenitors. Targetted knock out of Ndfip1 results in deregulation of the cell cycle in the neuroprogenitors but in the adult, lack of Ndfip1 causes degenerative problems in the cortex.