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Category CDBセミナー
Date and Time 2012-07-13 16:30 - 17:30
Venue Seminar Room A7F
Speaker Kazutoshi Takahashi
Affiliation CiRA, Kyoto Univerisity
Title Dissecting the route of human cellular reprogramming
Poster click here to download(PDF)
Host Hitoshi Niwa
Summary The latent pluripotency of somatic cells can be recaptured by the transduction of such transcription factors as OCT3/4, SOX2, KLF4 and c-MYC for a few weeks. However, both the detailed dynamic state of reprogramming cells and the route of reprogramming still remain unsolved because large numbers of non-reprogrammed cells, which are caused by the low efficiencies of certain reprogramming methodologies, have been identified in certain analyses. We herein show an improved reprogramming cell capture system, using a pluripotent cell-specific surface antigen called TRA-1-60, and also elucidate that reprogramming cells share common features with early mammalian development.
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