セミナー・イベント

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Category CDBセミナー
Date and Time 2015-11-30 14:30 - 15:30
Venue Auditorium C1F
Speaker Azusa Inoue
Affiliation Yi Zhang's Lab, Harvard Medical School/Boston Children's Hospital, USA
Title Genome-wide remodeling of sperm epigenome upon fertilization
Poster click here to download(PDF)
Host Tomoya Kitajima
Summary In the life cycle of mammals, there is no other stage than fertilization where chromatin is genome-widely assembled de novo from the beginning. Fertilization therefore provides an excellent model for studying epigenetic reprogramming and chromatin function. I would like to talk about how chromatin remodeling of sperm epigenome proceeds in mouse preimplantation embryos. The topics I will talk include;

1). Mechanism of DNA demethylation
2). An unprecedented role of nucleosomes in nuclear pore complex assembly revealed by generation of histone-free nuclei
3). Genome-wide mapping of accessible chromatin in preimplantation embryos
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