Seminars and Events

Past Events

Category Seminar
Date and Time 2006-09-19 13:30 - 14:30
Venue Auditorium C1F
Speaker Herbert Steinbeisser
Affiliation Institute of Human Genetics, University of Heidelberg, Germany
Title How to get in shape: regulation of morphogenesis in the early Xenopus embryo
Poster click here to download(PDF)
Host Yoshiki Sasai
Summary During gastrulation the Xenopus embryo has to develop two important morphogenetic cell behaviours. Cells of the mesoderm have to perform convergent-extension (CE) movements, which result in the establishment of the anterior-posterior (AP) body axis. Involuting mes-endoderm and ectoderm have to develop tissue separation (TS) behaviour in order to prevent mixing of the germ layers. Recent experiments suggest that non-canonical Wnt-signalling pathways are involved in the regulation of CE and TS. We have identified the receptor Frizzled 7 (Xfz7) and the Paraxial Protocadherin (PAPC) as components of the gastrula morphogenesis machinery. In the context of CE and TS the C-terminus of PAPC has signalling functions which modulates non canonical Wnt-signalling pathways. In a yeast two hybrid screen we have identified proteins which functionally connect PAPC and the Wnt pathways.