Exploration of Mechanotransduction in Cells: Mechano-Sensing by Physical Extension of the Src Family Kinase Substrate p130Cas Center for Developmental Biology

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Category	Seminar
Date and Time	2007-03-22 11:00 - 12:00
Venue	Seminar Room A7F
Speaker	Yasuhiro Sawada
Affiliation	Department of Biological Sciences, Columbia University, New York, NY, U.S.A.
Title	Exploration of Mechanotransduction in Cells: Mechano-Sensing by Physical Extension of the Src Family Kinase Substrate p130Cas
Poster	click here to download(PDF)
Host	Asako Sugimoto
Summary	Mechanical factors are involved in a number of biological phenomena including development, carcinogenesis, tissue regeneration, bone homeostasis, cardiovascular disorder, and neurogenesis. Recently, mechanically-initiated signal transduction, termed mechanotransduction, has been extensively studied. However, direct mechano-sensors that convert physical information into biochemical signals have not been identified aside from ion channels. Using an in vitro protein extension system, we found that p130Cas acts as a mechano-senor in the cytoskeleton by modulating its susceptibility to phosphorylation. We propose such 'substrate priming' is a general mechanism in the regulation of cell signaling. Reference: Sawada, Y. et al., "Force sensing by mechanical extension of the Src family kinase substrate p130Cas", Cell 127, 1015-1026 (2006)