Insights into intestinal homeostasis from Drosophila: stochastic fate allocation and stress-induced exit from quiescence Center for Developmental Biology

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Category	Seminar
Date and Time	2013-02-07 16:00 - 17:00
Venue	Seminar Room A7F
Speaker	Joaquín de Navascués
Affiliation	Department of Genetics, University of Cambridge
Title	Insights into intestinal homeostasis from Drosophila: stochastic fate allocation and stress-induced exit from quiescence
Poster	click here to download(PDF)
Host	Shigeo Hayashi
Summary	The homeostatic maintenance of intestinal epithelium is subject of interest due to its medical relevance and its value as a model for studying stem cell function. For decades, intestinal homeostasis has been thought to rely on stem cells that divide asymmetrically and to proceed by continuous self-renewal. I will present work showing that the adult Drosophila intestine, previously thought to behave asymmetrically, is maintained through symmetric divisions resolved stochastically, in parallel with recent findings in the mammalian gut. I will also discuss how this behaviour could be molecularly regulated. Finally, I will present evidence that the Drosophila intestine is not in continuous renewal, but rather in a state of quiescence that can be stimulated to division by stress.