Developmental Control of Replication Timing and Chromosome Architecture Center for Developmental Biology

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Category	Seminar
Date and Time	2016-11-11 16:00 - 17:00
Venue	Seminar Room A7F
Speaker	David M. Gilbert
Affiliation	Florida State University
Title	Developmental Control of Replication Timing and Chromosome Architecture
Poster	click here to download(PDF)
Host	Ichiro Hiratani
Summary	Replication timing (RT) is regulated in units of several hundred kilobases ("Replication Domains"; RDs), over half of which undergo RT changes during differentiation (developmental RDs). RDs correspond to topologically associating domains (TADs), which are structural units detected by chromosome conformation capture. TADs with similar RT tend to interact, creating spatio-temporally segregated sub-nuclear compartments. Developmental RDs exhibit altered RT regulation in cancer, creating sub-type specific and patient-specific RT "fingerprints", some of which can be traced to the primitive cell type of origin. Our work attempts to understand what regulates RT and its biological significance to development and cancer.