Seminars and Events

Past Events

Category Seminar
Date and Time 2016-11-11 16:00 - 17:00
Venue Seminar Room A7F
Speaker David M. Gilbert
Affiliation Florida State University
Title Developmental Control of Replication Timing and Chromosome Architecture
Poster click here to download(PDF)
Host Ichiro Hiratani
Summary Replication timing (RT) is regulated in units of several hundred kilobases ("Replication Domains"; RDs), over half of which undergo RT changes during differentiation (developmental RDs). RDs correspond to topologically associating domains (TADs), which are structural units detected by chromosome conformation capture. TADs with similar RT tend to interact, creating spatio-temporally segregated sub-nuclear compartments. Developmental RDs exhibit altered RT regulation in cancer, creating sub-type specific and patient-specific RT "fingerprints", some of which can be traced to the primitive cell type of origin. Our work attempts to understand what regulates RT and its biological significance to development and cancer.