Seminars and Events

Past Events

Category Seminar
Date and Time 2016-11-28 16:00 - 17:00
Venue Seminar Room A7F
Speaker Stefano De Renzis
Affiliation European Molecular Biology Laboratory (EMBL), Germany
Title Shaping Cells and Tissues: from Embryonic Development to Synthetic Biology
Poster click here to download(PDF)
Host Yu-Chiun Wang
Summary Morphogenesis of multicellular organisms is characterized by changes in cell and tissue behaviors that occur at specific space and time in a coordinated manner. This stereotypic and genetically encoded spatio-temporal organization makes it difficult to determine the extent to which individual cell behavior drive morphological remodeling. In my talk I will describe an optogenetic-based synthetic approach that allowed us to reconstitute epithelial folding in naïve Drosophila embryonic tissues. I will presents experiments showing that precise spatial and temporal activation of Rho signaling is sufficient to trigger apical constriction and tissue folding independently of any pre-determined physical and biochemical conditions or other tissue-scale properties that accompany endogenous invagination processes. Synthetic furrows can occur at any position along the d-v or a-p embryo axis in response to the spatial pattern and level of optogenetic activation. These results suggest that epithelial folding is, thus, a direct function of the spatio-temporal organization and strength of Rho signaling that is on its own sufficient to drive tissue invagination.